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PROGRAMME AT A GLANCE

Thursday 23 May 2024 – ECR WORKSHOP

 
08:30 – 09:00      Networking breakfast
09:00 – 09:40       Delivering translation

My career in translational research

Professor Sir Adrian Hill, Director and Founder of the Jenner Institute, Mittal Professor of Vaccinology at Oxford University

How to influence policy and interact with policy makers

Professor Marian Knight MBE, NIHR Scientific Director for Research Infrastructure and Co-Director of the NIHR Policy Research Unit in Maternal and Neonatal Health and Care

09:40 – 10:10        Surviving the clinical academic pathway

Improving the academic clinical pathway

Professor David Jones OBE, Director, NHIP Academy, Director, Newcastle Centre for Rare Disease & Professor of Liver Immunology, Newcastle University

The North East Mentoring Organisation (NEMO)

Dr Louise Swan, Consultant in Critical Care Medicine and Anaesthetics, Royal Victoria Infirmary, Newcastle Upon Tyne

10:10 – 10:35         Tea and Coffee
Opportunity to sign up to mentoring session with North East England Mentoring Organisation (NEMO)
10:35 – 12:10         Strategies to support the next generation of clinical academics: Short Talks 

AoPGBI: Professor Sarah Walmsley, Chair of the Internal Affairs Committee and Executive Committee member for the AoPGBI, and Chair of Respiratory Medicine, Centre for Inflammation Research

NIHR: Professor Waljit Dhillo, Professor in Endocrinology and Metabolism / Consultant Endocrinologist / NIHR Senior Investigator, Dean of the NIHR Academy

MRC: Professor Patrick Chinnery, MRC Executive Chair & Professor of Neurology at the University of Cambridge, Honorary Consultant Neurologist at Addenbrooke’s Hospital

NHS: Sir James Mackey, Chief Executive, Newcastle upon Tyne Hospitals NHS FT

JRCPTB: Dr Mike Jones, Medical Director for Training and Development, Federation of Royal Colleges of Physicians

Wellcome: Dr Ben Murton, Head of Early Career and Career Development Researchers – Discovery Research, Wellcome

Thursday 23 May 2024 – MAIN MEETING PROGRAMME

13:00 – 15:10         Symposium 1 – Open theme in Partnership with the American Society of Clinical Investigation (ASCI)

                                       Joint Chairs:

                                       Professor Chris Day CBE

                                       Vice-Chancellor and President of Newcastle University

                                       Professor Hossein Ardehali

                                       Cardiologist, Northwestern University School of Medicine, Past president of ASCI, Deputy Editor of the JCI

13:00 -13:08          Welcome & Presentation of Award for Outstanding Contribution to Translational Medicine

                                       Professor Chris Day CBE

                                       Vice-Chancellor and President of Newcastle University

                                       AoP Honorary Secretary: Professor Julian Knight

                                       Professor of Genomic Medicine at the University of Oxford 

13:08 -13:13          Welcome from Partner – ASCI

                                       Professor Hossein Ardehali

                                       Cardiologist, Northwestern University School of Medicine, Past president of ASCI, Deputy Editor of the JCI

13:13 -13:38          The George Griffin Lecture

Developing malaria vaccines – a translational odyssey
Professor Sir Adrian Hill,
Founder of the Jenner Institute,
Mittal Professor of Vaccinology at Oxford University

13:38 -14:38

Oral Presentations 

Divergent performance of bivalent BA.5 and monovalent XBB.1.5 COVID-19 vaccines given as annual booster
Dr Emma Wall
Francis Crick Institute

Endogenous retroelement activation is implicated in IFN-α production and anti-CCP autoantibody generation in early RA
Dr Faye Cooles
Newcastle University

Impact of BRAF inhibitor pretreatment on checkpoint inhibitor efficacy in metastatic melanoma
Dr Martin Little
University of Oxford

Circulating Neutrophil Metabolic Adaptions Within Acute and Convalescent Acute Respiratory Distress Syndrome Patients
Mr George Cooper
Edinburgh Medical School

Profiling immune cell responses in chronic rejection after lung transplantation using imaging mass cytometry
Dr Saskia Bos (to be presented by Professor Andrew Fisher)
Newcastle University

Neutrophil and T cell interaction in metastatic non-small cell lung cancer
Dr Caroline Bruce
University of Edinburgh

14:38-14:53          Q&A Discussion
14:53 -15:08          Flash Posters
15:10 – 15:30         Tea and Coffee and Poster viewing
15:30 – 17:40        Symposium 2 – Rare Diseases in Partnership with Life Arc

                                       Joint Chairs:

                                       Professor David Jones OBE

                                       Director, NHIP Academy, Director, Newcastle Centre for Rare Disease & Professor of Liver Immunology, Newcastle University

                                       Dr Catriona Crombie

                                       Head of Rare Disease, LifeArc

15:30 – 15:35         Welcome from Partner – LifeArc

                                       Dr Catriona Crombie

                                       Head of Rare Disease, LifeArc

15:35 – 16:00         Plenary

Learning from inborn errors of immunity, a paradigm for precision medicine
Professor Sophie Hambleton
Professor of Paediatrics and Immunology, Deputy Dean, Translational and Clinical Research Institute
Immunity & Inflammation Theme Lead, Newcastle University

16:00 – 16:40

Oral Presentations 

Expanding the clinical and genetic spectrum of congenital disorders of macroautophagy
Professor Rob Taylor
Newcastle University

Biallelic variants in RCC1 are associated with Acute Onset Axonal Neuropathy with/without encephalopathy
Professor William Newman
University of Manchester

Nuclear Genetics Influence the Presentation of Rare, Maternally-Inherited Mitochondrial DNA Disease
Dr Sarah Pickett
Newcastle University

Investigating Health Status and Quality of Life in Patients with STAT3 Hyper-IgE Syndrome 
Dr Christo Tsilifis
Translational and Clinical Research Institute, Newcastle University

16:40 – 17:05         Plenary

From translational research to improved care for people with rare diseases
Professor Volker Straub
Harold Macmillan Professor of Medicine
Director of The John Walton Muscular Dystrophy Research Centre, Newcastle University

17:05 – 17:20         Q&A Discussion
17:20 – 17:40         Flash Posters
17:40 – 17:45          Mentor / Mentee Pitch – AoP’s new mentoring programme
17:45 – 18:00          Poster viewing
18:00 – 19:15         Networking at the Frederick Douglass Centre Evening
19:30 – 23:00         Dinner at Six restaurant

Friday 24 May 2024 – MAIN MEETING PROGRAMME

09:00 -10:50         Symposium 3 – Ageing and Multimorbidity in Partnership with the Lancet

                                       Joint Chairs:

                                       Professor David Burn

                                       Pro-Vice Chancellor and Professor of Movement Disorders Neurology, Newcastle University

                                       Dr Jonathan Pimm

                                       Senior editor, The Lancet, Consultant psychiatrist

09:00 – 09:05       Welcome from Partner – the Lancet

                                       Dr Jonathan Pimm

                                       Senior editor, The Lancet, Consultant psychiatrist

09:05 – 09:30        Plenary

From translational ageing research to new horizons for sarcopenia
Professor Avan Aihie Sayer
William Leech Chair of Geriatric Medicine
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University

09:30 – 10:10

Oral Presentations 

Genome-wide association study on metabolic dysfunction-associated steatotic liver disease (MASLD): identification of six genome-wide significant signals
Professor Ann Daly
Newcastle University

A neutrophil phenotype associated with response to locoregional therapy in patients with hepatocellular carcinoma (HCC)
Professor Helen Reeves
Newcastle University

Severe eczema is associated with prolonged reaction times and increased depressive thought prevalence, but not grey or white matter integrity
Dr Jill Betts
Oxford University Hospitals NHS Foundation Trust

The Rheumatoid Arthritis and MUScle (RAMUS) study: does tofacitinib reverse sarcopenia in RA?
Dr Joshua Luke Bennett
Newcastle University

10:10 – 10:35         Plenary

Improving evidence-based clinical and policy decisions in multimorbidity
Professor Bruce Guthrie
Professor of General Practice, Director Advanced Care Research Centre, University of Edinburgh

10:35 – 10:50         Q&A Discussion
10:50 – 11:10         Tea and Coffee
11:10 – 13:10         Symposium 4 – Population Health & Data Science in Partnership with HDR UK

Joint Chairs:

Professor Sophie Hambleton

Professor of Paediatrics and Immunology, Deputy Dean, Translational and Clinical Research Institute, Newcastle University

                                        Mr Amarpreet Singh Judge                                     

                                        Head of External Affairs, HDR UK

11:10 – 11:15         Welcome from Partner – HD UK

                                      Mr Amarpreet Singh Judge                                     

                                      Head of External Affairs, HDR UK

11:15 – 11:40         Plenary

Unifying Health Data in the UK
Professor Cathie Sudlow
Chief Scientist & Deputy Director of HDR UK, and Director of the BHF Data Science Centre
Chair of Neurology and Clinical Epidemiology at the University of Edinburgh

11:40 – 12:30

Oral Presentations 

Predictive performance of cardiovascular risk scores in cancer survivors from the UK Biobank
Dr Zahra Raisi-Estabragh
William Harvey Research Institute

Maternal type 1 diabetes offers long-term relative protection against type 1 diabetes in the offspring
Dr Lowri Allen
Cardiff University

Does the Importance of Risk Factors Vary by Stroke Severity? An Analysis of the INTERSTROKE study
Dr Catriona Reddin
University of Galway

Longitudinal study of NAFLD progression using paired biopsies in a well-characterised European cohort
Dr Anastasia Resteu
Newcastle University

Mortality after moving-in to a care home: a national data linkage study
Dr Jenni Burton
University of Glasgow

12:30 – 12:55         Plenary

Evolution revealed through large-scale population genomics: impact for human health
Professor Patrick Chinnery
Professor of Neurology at the University of Cambridge, Honorary Consultant Neurologist at Addenbrooke’s
Hospital

12:55 – 13:10         Q&A Discussion
13:10 – 14:00         Lunch and Poster Viewing
14:00 – 15:55         Symposium 5 – Novel therapies and diagnostics in Partnership with Science Translational Medicine 

Joint Chairs:

Professor Quentin Anstee

Dean of Research & Innovation; Professor of Experimental Hepatology, Newcastle University

Dr Orla Smith

Managing Editor, Science Translational Medicine

14:00 – 14:05         Welcome from Partner – Science Translational Medicine

                                        Dr Orla Smith

                                        Managing Editor, Science Translational Medicine

14:05 – 14:30         The Osler Lecture

Human variation: the key to personalised treatment
Professor Mary Reilly
Professor of clinical neurology and consultant neurologist, University College London

14:30 – 15:00

Oral Presentations 

Assessing the response to antimiR-21 in a human model of kidney ischaemia reperfusion injury
Dr Emily Glover
Newcastle University

Relationship between asthma duration and FEV1 among distinct severe asthma phenotypes
Dr Freda Yang
Imperial College London

Proteo-transcriptomics identifies circulating protein signatures associated with disease activity in Metabolic dysfunction-associated steatotic liver disease
Dr Olivier Govaere
Newcastle University

15:00 – 15:25         Plenary

Lynch syndrome: a case study in cancer prevention
Professor Sir John Burn
Professor of Clinical Genetics, Translational and Clinical Research Institute, Newcastle University

15:25 – 15:40         Q&A Discussion
15:40 – 15:45         Fellows Inauguration
15:45 – 15:55         Prizes and close
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