PROGRAMME AT A GLANCE
Thursday 23 May 2024 – ECR WORKSHOP
08:30 – 09:00 Networking breakfast
09:00 – 09:40 Delivering translation
My career in translational research
Professor Sir Adrian Hill, Director and Founder of the Jenner Institute, Mittal Professor of Vaccinology at Oxford University
How to influence policy and interact with policy makers
Professor Marian Knight MBE, NIHR Scientific Director for Research Infrastructure and Co-Director of the NIHR Policy Research Unit in Maternal and Neonatal Health and Care
09:40 – 10:10 Surviving the clinical academic pathway
Improving the academic clinical pathway
Professor David Jones OBE, Director, NHIP Academy, Director, Newcastle Centre for Rare Disease & Professor of Liver Immunology, Newcastle University
The North East Mentoring Organisation (NEMO)
Dr Louise Swan, Consultant in Critical Care Medicine and Anaesthetics, Royal Victoria Infirmary, Newcastle Upon Tyne
10:10 – 10:35 Tea and Coffee
Opportunity to sign up to mentoring session with North East England Mentoring Organisation (NEMO)
10:35 – 12:10 Strategies to support the next generation of clinical academics: Short Talks
AoPGBI: Professor Sarah Walmsley, Chair of the Internal Affairs Committee and Executive Committee member for the AoPGBI, and Chair of Respiratory Medicine, Centre for Inflammation Research
NIHR: Professor Waljit Dhillo, Professor in Endocrinology and Metabolism / Consultant Endocrinologist / NIHR Senior Investigator, Dean of the NIHR Academy
MRC: Professor Patrick Chinnery, MRC Executive Chair & Professor of Neurology at the University of Cambridge, Honorary Consultant Neurologist at Addenbrooke’s Hospital
NHS: Sir James Mackey, Chief Executive, Newcastle upon Tyne Hospitals NHS FT
JRCPTB: Dr Mike Jones, Medical Director for Training and Development, Federation of Royal Colleges of Physicians
Wellcome: Dr Ben Murton, Head of Early Career and Career Development Researchers – Discovery Research, Wellcome
Thursday 23 May 2024 – MAIN MEETING PROGRAMME
13:00 – 15:10 Symposium 1 – Open theme in Partnership with the American Society of Clinical Investigation (ASCI)
Joint Chairs:
Professor Chris Day CBE
Vice-Chancellor and President of Newcastle University
Professor Hossein Ardehali
Cardiologist, Northwestern University School of Medicine, Past president of ASCI, Deputy Editor of the JCI
13:00 -13:08 Welcome & Presentation of Award for Outstanding Contribution to Translational Medicine
Professor Chris Day CBE
Vice-Chancellor and President of Newcastle University
AoP Honorary Secretary: Professor Julian Knight
Professor of Genomic Medicine at the University of Oxford
13:08 -13:13 Welcome from Partner – ASCI
Professor Hossein Ardehali
Cardiologist, Northwestern University School of Medicine, Past president of ASCI, Deputy Editor of the JCI
13:13 -13:38 The George Griffin Lecture
Developing malaria vaccines – a translational odyssey
Professor Sir Adrian Hill,
Founder of the Jenner Institute,
Mittal Professor of Vaccinology at Oxford University
13:38 -14:38
Oral Presentations
Divergent performance of bivalent BA.5 and monovalent XBB.1.5 COVID-19 vaccines given as annual booster
Dr Emma Wall
Francis Crick Institute
Endogenous retroelement activation is implicated in IFN-α production and anti-CCP autoantibody generation in early RA
Dr Faye Cooles
Newcastle University
Impact of BRAF inhibitor pretreatment on checkpoint inhibitor efficacy in metastatic melanoma
Dr Martin Little
University of Oxford
Circulating Neutrophil Metabolic Adaptions Within Acute and Convalescent Acute Respiratory Distress Syndrome Patients
Mr George Cooper
Edinburgh Medical School
Profiling immune cell responses in chronic rejection after lung transplantation using imaging mass cytometry
Dr Saskia Bos (to be presented by Professor Andrew Fisher)
Newcastle University
Neutrophil and T cell interaction in metastatic non-small cell lung cancer
Dr Caroline Bruce
University of Edinburgh
14:38-14:53 Q&A Discussion
14:53 -15:08 Flash Posters
15:10 – 15:30 Tea and Coffee and Poster viewing
15:30 – 17:40 Symposium 2 – Rare Diseases in Partnership with Life Arc
Joint Chairs:
Professor David Jones OBE
Director, NHIP Academy, Director, Newcastle Centre for Rare Disease & Professor of Liver Immunology, Newcastle University
Dr Catriona Crombie
Head of Rare Disease, LifeArc
15:30 – 15:35 Welcome from Partner – LifeArc
Dr Catriona Crombie
Head of Rare Disease, LifeArc
15:35 – 16:00 Plenary
Learning from inborn errors of immunity, a paradigm for precision medicine
Professor Sophie Hambleton
Professor of Paediatrics and Immunology, Deputy Dean, Translational and Clinical Research Institute
Immunity & Inflammation Theme Lead, Newcastle University
16:00 – 16:40
Oral Presentations
Expanding the clinical and genetic spectrum of congenital disorders of macroautophagy
Professor Rob Taylor
Newcastle University
Biallelic variants in RCC1 are associated with Acute Onset Axonal Neuropathy with/without encephalopathy
Professor William Newman
University of Manchester
Nuclear Genetics Influence the Presentation of Rare, Maternally-Inherited Mitochondrial DNA Disease
Dr Sarah Pickett
Newcastle University
Investigating Health Status and Quality of Life in Patients with STAT3 Hyper-IgE Syndrome
Dr Christo Tsilifis
Translational and Clinical Research Institute, Newcastle University
16:40 – 17:05 Plenary
From translational research to improved care for people with rare diseases
Professor Volker Straub
Harold Macmillan Professor of Medicine
Director of The John Walton Muscular Dystrophy Research Centre, Newcastle University
17:05 – 17:20 Q&A Discussion
17:20 – 17:40 Flash Posters
17:40 – 17:45 Mentor / Mentee Pitch – AoP’s new mentoring programme
17:45 – 18:00 Poster viewing
18:00 – 19:15 Networking at the Frederick Douglass Centre Evening
19:30 – 23:00 Dinner at Six restaurant
Friday 24 May 2024 – MAIN MEETING PROGRAMME
09:00 -10:50 Symposium 3 – Ageing and Multimorbidity in Partnership with the Lancet
Joint Chairs:
Professor David Burn
Pro-Vice Chancellor and Professor of Movement Disorders Neurology, Newcastle University
Dr Jonathan Pimm
Senior editor, The Lancet, Consultant psychiatrist
09:00 – 09:05 Welcome from Partner – the Lancet
Dr Jonathan Pimm
Senior editor, The Lancet, Consultant psychiatrist
09:05 – 09:30 Plenary
From translational ageing research to new horizons for sarcopenia
Professor Avan Aihie Sayer
William Leech Chair of Geriatric Medicine
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
09:30 – 10:10
Oral Presentations
Genome-wide association study on metabolic dysfunction-associated steatotic liver disease (MASLD): identification of six genome-wide significant signals
Professor Ann Daly
Newcastle University
A neutrophil phenotype associated with response to locoregional therapy in patients with hepatocellular carcinoma (HCC)
Professor Helen Reeves
Newcastle University
Severe eczema is associated with prolonged reaction times and increased depressive thought prevalence, but not grey or white matter integrity
Dr Jill Betts
Oxford University Hospitals NHS Foundation Trust
The Rheumatoid Arthritis and MUScle (RAMUS) study: does tofacitinib reverse sarcopenia in RA?
Dr Joshua Luke Bennett
Newcastle University
10:10 – 10:35 Plenary
Improving evidence-based clinical and policy decisions in multimorbidity
Professor Bruce Guthrie
Professor of General Practice, Director Advanced Care Research Centre, University of Edinburgh
10:35 – 10:50 Q&A Discussion
10:50 – 11:10 Tea and Coffee
11:10 – 13:10 Symposium 4 – Population Health & Data Science in Partnership with HDR UK
Joint Chairs:
Professor Sophie Hambleton
Professor of Paediatrics and Immunology, Deputy Dean, Translational and Clinical Research Institute, Newcastle University
Mr Amarpreet Singh Judge
Head of External Affairs, HDR UK
11:10 – 11:15 Welcome from Partner – HD UK
Mr Amarpreet Singh Judge
Head of External Affairs, HDR UK
11:15 – 11:40 Plenary
Unifying Health Data in the UK
Professor Cathie Sudlow
Chief Scientist & Deputy Director of HDR UK, and Director of the BHF Data Science Centre
Chair of Neurology and Clinical Epidemiology at the University of Edinburgh
11:40 – 12:30
Oral Presentations
Predictive performance of cardiovascular risk scores in cancer survivors from the UK Biobank
Dr Zahra Raisi-Estabragh
William Harvey Research Institute
Maternal type 1 diabetes offers long-term relative protection against type 1 diabetes in the offspring
Dr Lowri Allen
Cardiff University
Does the Importance of Risk Factors Vary by Stroke Severity? An Analysis of the INTERSTROKE study
Dr Catriona Reddin
University of Galway
Longitudinal study of NAFLD progression using paired biopsies in a well-characterised European cohort
Dr Anastasia Resteu
Newcastle University
Mortality after moving-in to a care home: a national data linkage study
Dr Jenni Burton
University of Glasgow
12:30 – 12:55 Plenary
Evolution revealed through large-scale population genomics: impact for human health
Professor Patrick Chinnery
Professor of Neurology at the University of Cambridge, Honorary Consultant Neurologist at Addenbrooke’s
Hospital
12:55 – 13:10 Q&A Discussion
13:10 – 14:00 Lunch and Poster Viewing
14:00 – 15:55 Symposium 5 – Novel therapies and diagnostics in Partnership with Science Translational Medicine
Joint Chairs:
Professor Quentin Anstee
Dean of Research & Innovation; Professor of Experimental Hepatology, Newcastle University
Dr Orla Smith
Managing Editor, Science Translational Medicine
14:00 – 14:05 Welcome from Partner – Science Translational Medicine
Dr Orla Smith
Managing Editor, Science Translational Medicine
14:05 – 14:30 The Osler Lecture
Human variation: the key to personalised treatment
Professor Mary Reilly
Professor of clinical neurology and consultant neurologist, University College London
14:30 – 15:00
Oral Presentations
Assessing the response to antimiR-21 in a human model of kidney ischaemia reperfusion injury
Dr Emily Glover
Newcastle University
Relationship between asthma duration and FEV1 among distinct severe asthma phenotypes
Dr Freda Yang
Imperial College London
Proteo-transcriptomics identifies circulating protein signatures associated with disease activity in Metabolic dysfunction-associated steatotic liver disease
Dr Olivier Govaere
Newcastle University
15:00 – 15:25 Plenary
Lynch syndrome: a case study in cancer prevention
Professor Sir John Burn
Professor of Clinical Genetics, Translational and Clinical Research Institute, Newcastle University
