In this webinar we look at ‘Inflammation Across Tissues‘

Immune Mediated Inflammatory Diseases (IMIDs) are a common and growing problem. Traditional models of research and service delivery silo their management within specific specialities and within adult or paediatric settings. Very often patients with disease in one organ have co-morbid involvement in another, suggesting shared pathogenic pathways. Moreover, IMIDs are often treated in very similar ways (combination therapy) with very similar drugs (steroids and anti TNF biologics). In this seminar we will explore how investigating these diseases in a common manner has led to some startling findings that not only unlock the cellular basis of these diseases but have implications for the rapid assessment of the efficacy of new therapeutic targets in cross-disease translational research studies.

Learning goals:

1. To understand the way in which genes and the environment interact to lead to polygenic cross IMID disorders in children and adults
2. To explore the cellular processes that underpin different diseases to new or repurposed drugs that either target a shared pathogenic mechanism or are disease specific
3. To learn about cross-disease, cross-discipline basket-trials (one drug across two or more disease) to de-risk early-stage trials of drugs that target IMIDs.

Aimed at all health care practitioners interested in treating and assessing inflammatory diseases in adults and children as well as those who design clinical trials in the NHS, academia and industry.